He has served as a Professor of Mechanical and Biomedical Engineering, Florida International University. He moved to Texas A&M University in 2003, Director of Graduate Studies. In January 2013, he joined Imperial College as the Bagrit and Royal Academy of Engineering Chair in Medical Device Design.

His research interests include Cardiovascular Biomechanics, Implantable Devices, Atherosclerosis, and the Lymphatic System. His research focuses on the role of biomechanics in the formation and treatment of diseases such as atherosclerosis and cancer.

His cardiovascular biomechanics research includes the first studies of the effects of combined flow and stretch on vascular endothelium, and the first studies of the effects of stents on both blood flow patterns and artery wall stress. This work resulted in the development of two novel stent designs aimed at optimizing post-implant biomechanics for the prevention of restenosis.  

His research on lymphatic system biomechanics has provided unprecedented insight into the pumping characteristics of the system and the transport of nitric oxide, antigens, and chemokines. He is currently developing two technologies for preventing and resolving secondary lymphedema, which typically forms subsequent to cancer surgery. Along with his funding from government, charity, and industry sources, he has received multiple patents for medical devices and testing equipment.  Jimmy has also co-founded two start-up companies.